华中科技大学化学与化工学院 华中科技大学化学与化工学院

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姓 名: 李海玲   Hailing Li
出生年月:1968-10
学历: 研究生
职称: 副教授
专业方向:生物无机化学
电 话:15972206351
Email:lihailing86@hust.edu.cn
个人主页:

教育与研究经历

2004/09 – 2008/06,华中科技大学,化学与化工学院,博士

1996/09 – 1999/06,华中理工大学,化学系,硕士

            1986/09 – 1989/06,重庆科技学院,化学系

研究领域与兴趣

1. 天然产物提取及分析

2. 铁过载损伤机理

教学情况

讲授《基础化学》、《基础化学实验》、《综合实验》

承担项目与课题

国家自然科学基金

基于蛋白质酪氨酸硝化的铁过载促进胰岛素抵抗的分子机制及黄芩苷的干预作用研究(N0. 31570810)

代表性成果

一. 第一及通讯作者论文:

1. Jinming Wu, Jie Zhao, Zhen Yang, Hailing Li*, Zhonghong Gao*.A strong inhibitory effect of heme on hIAPP fibrillation. Chemical Research in Toxicology. 2017, 30(9):1711-1719  

2. Yi Huang, Zhen Yang, Huan Xu, Pengfei Zhang, Zhonghong Gao, Hailing Li*. Insulin enhances the peroxidative activity of heme by forming heme-insulin complex: relevance to type 2 diabetes mellitus. International Journal of Biological Macromolecules. 2017, 102: 1009-1015

3. Wanxia Gao, Jie Zhao, Zhonghong Gao, Hailing Li*. Synergistic interaction of light alcohol administration in the presence of mild iron overload in a mouse model of liver injury: involvement of triosephosphate isomerase nitration and inactivation. PLoS One. 2017 Jan 19;12(1):e0170350

4. Xueli Li, Wenliang Li, Zhonghong Gao, Hailing Li*. Association of cardiac injury with iron-increased oxidative and nitrative modifications of the SERCA2a isoform of sarcoplasmic reticulum Ca(2+)-ATPase in diabetic rats. Biochimie. 2016, 127:144-52

5. Yun-Chao Feng, Wen-Liang Li , Fa-Mei He, Tao-Tao Kong, Xiao-Wei Huang, Zhong-Hong Gao, Naihao Lu, Hailing Li*. Aqueous two - phase system as an effective tool for purification of phenolic compounds from fig fruits (Ficus carica L.). Separation Science and Technology. 2015, 50(12): 1785-1793

6. Wanxia Gao, Xueli Li, Zhonghong Gao, Hailing Li*. Iron increases diabetes-induced kidney injury and oxidative stress in rats. Biological Trace Element Research. 2014, 160(3):368-75

7. Xiaowei Huang, Yunchao Feng, Yi Huang, Hailing Li*. Chemical composition, antioxidant, and the possible use as skin-care ingredient of clove oil (Syzygium aromaticum (L.) Merr. & Perry) and citronella oil (Cymbopogon goeringii) from China. Journal of Essential Oil Research. 2013, 25(4): 315-323.

8. Xiaowei Huang, Yunchao Feng, Yi Huang, Hailing Li*. Potential cosmetic application of essential oil extracted from Litsea cubeba fruits from China. Journal of Essential Oil Research. 2013, 25(2): 112-119.

9. Xueli Li, Hailing Li*, Naihao Lu, Yunchao Feng, Yi Huang, Zhonghong Gao*. Iron increases liver injury through oxidative/nitrative stress in diabetic rats: involvement of nitrotyrosination of glucokinase. Biochimie. 2012, 94, 2620-2627.

10. Yan Xu, Yunchao Feng, Hailing Li*, Zhonghong Gao*. Ferric citrate CYP2E1-independently promotes alcohol-induced apoptosis in HepG2 cells via oxidative/nitrative stress which is attenuated by pretreatment with baicalin. Food and Chemical Toxicology. 2012, 50: 3264-3272

11. Xiaowei Huang, Lian Yi, Zhonghong Gao, Hailing Li*. Simultaneous determination of seven active ingredients in three plant essential oils by using micellar electrokinetic chromatography. Analytical Letters. 2012, 45(14):2014-2025

12. Naihao Lu, Lian Yi, Qinqin Deng, Jinyang Li, Zhonghong Gao, Hailing Li*. The interaction between desferrioxamine and hemin: A potential toxicological implication. Toxicology in Vitro 2012, 26: 732–735

13. Yan Zhang, Yi Huang, Xiaorong Deng, Yan Xu, Zhonghong Gao, Hailing Li*. Iron overload-induced rat liver injury: involvement of protein tyrosine nitration and the effect of baicalin. European Journal of Pharmacology.2012, 680(1-3): 95-101

14. Lian Yi, Hailing Li*, Qingqing Deng, Zhongzheng Yuan. Study of nobiletin binding to bovine serum albumin by capillary electrophoresis-frontal analysis and circular dichroism.Biomedical Chromatography. 2010, 24(9):1023-1028.

15. Hailing Li, Huibi Xu, Zhonghong Gao*. Determination of 3-Nitrotyrosine by Micellar Electrokinetic Chromatography with on-Column High-Salt Stacking. Chinese Journal of Analytical Chemistry. 2007, 35(8):1087-1091.

二、第一发明人获得授权专利:

1. 一种从油菜饼中提取精制茶皂素的方法 ,专利号:ZL 2010 1 0589881.7

2. 一种1-(3-巯基-2-D-甲基丙酰基)-L-脯氨酸的合成方法,专利号:ZL 2011 1 0349096.9