华中科技大学化学与化工学院 华中科技大学化学与化工学院

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姓 名: 夏帆   Xia Fan
出生年月:1980-12
学历: 博士
职称: 教授
专业方向:生物传感器、生物分子
电 话:027-87559484
Email:xiafan@hust.edu.cn
个人主页:

教育与研究经历

2012年-今  ,华中科技大学化学与化工学院(教授,博士生导师)

2008-2012,美国加州大学圣塔巴巴拉分校,导师:Alan J. Heeger 教授 (2000年诺贝尔化学奖获得者)、 Kevin W. Plaxco 教授 

2003-2008,中国科学院化学研究所,导师:江雷 教授(中国科学院院士)

1999-2003,华中科技大学,化学与化工学院,理学学士

                     华中科技大学,获得科技英语,  文学学士(通过专业英语八级考试)

研究领域与兴趣

目前主要从事的研究领域包括生物传感器、生物分子响应性纳米孔道的研究等。迄今为止,已在国际核心期刊上发表SCI论文60余篇IF>1018篇)。SCI引用3000余次,H因子25。发表的论文其中10篇单篇他引用次数超过100次。研究成果受到国内外同行的高度关注,多次被NatureNature ChinaNano TodayNPG等期刊或网站选为研究亮点。

获得中组部第四批“青年千人计划”人才支持,科技部青年973首席科学家,湖北省“百人计划”支持,湖北省特聘专家。

 

 

            

承担项目与课题

1.      基于响应性生物探针设计的微纳米器件用于乳腺癌早期检测的基础研究国家重大科学研究计划青年科学家项目计划,首席科学家  

2.       响应性脱氧核糖核酸分子设计与生物分子检测 (青年千人计划启动基金)

3.       基于循环探针技术的乳腺癌早期检测研究 (华中科技大学人才引进基金)

4.       微纳米尺度限域下的核酸自组装过程研究 (国家自然科学基金面上项目)

学术兼职

       1.  “千人计划”专家联谊会青年千人专业委员会委员代表  (2013)

       2.  中国材料研究学会纳米材料与器件分会第一届理事会理事   (2013)

代表性成果

1.Yongmei Jia, Xiaolei Zuo, Xiaoding Lou, Mao Miao, Yong Cheng, Xuehong Min , Xinchun Li, Fan Xia*.“Rational designed bipolar, conjugated polymer-DNA composite beacon for the sensitive detection of proteins and ionsAnalytical Chemistry,2015,87,3890.

2.Nannan Liu, Zekun Yang,Xiaoding Lou, Benmei Wei, Juntao Zhang, Pengcheng Gao, Ruizuo Hou, Fan Xia*.“Nanopore-Based DNA-Probe Sequence-Evolution Method Unveiling Characteristics of Protein-DNA Binding Phenomena in a Nanoscale Confined Space” Analytical Chemistry,2015,87,4037.

3.Wei Guo, Fan Hong, Nannan Liu, Jiayu Huang , Boya Wang, Ruixue Duan, Xiaoding Lou, Fan Xia*.“Target-Specific 3D DNA Gatekeepers for Biomimetic NanoporesAdvance Materials,2015,27,2090.

4.Tianchi Zhang, Chunli Shang, Ruixue Duan, Abdul Hakeem, Zhenyu Zhang, Xiaoding Lou, Fan Xia*.“Polar organic solvents accelerate the rate of DNA strand replacement reaction” Analyst,2015,140,2023.

5.Ruixue Duan, Boya Wang, Fan Hong, Tianchi Zhang, Yongmei Jia, Jiayu Huang, Abdul Hakeem, Nannan Liu, Xiaoding Lou, Fan Xia*.“Real-time monitoring of enzyme-free strand displacement cascades by colorimetric assays”Nanoscale,2015,7,5719.

6.Benmei Wei,Nannan Liu, Juntao Zhang, Xiaowen Ou, Ruixue Duan, Zekun Yang,Xiaoding Lou,Fan Xia*.“Regulation of DNA Self-Assembly and DNA Hybridization by Chiral Molecules with Corresponding Biosensor Applications” Analytical Chemistry,2015, 87, 2058.

7.Lou Xiaoding, Zhuang Yuan, Zuo Xiaolei, Jia Yongmei , Hong Yuning ,Min Xuehong, Zhang Zhenyu, Xu Xuemei ,Liu Nannan ,Xia Fan*, “Real-Time, Quantitative Lighting-up Detection of Telomerase in Urines of Bladder Cancer Patients by AIEgens”Analytical Chemistry, 2015, 87, 6822.

8.Di kang, Ruixue Duan,Fan Xia*, et al.“Speeding upthe self-assembly of a DNA nanodevice using a variety of polar solvents”Nanoscale,2014,6,14157.

9.Abdul Hakeem, Ruixue Duan ,Fan Xia*, et al. Dual stimuli-responsive nano-vehicles for controlled drug delivery:mesoporous silicananoparticles end-capped with natural chitosan”Chemical Communications,2014,50,13268.

10.Xiaoding Lou, Zujin Zhao, Fan Xia*, et al.“A new turn-on chemosensor for bio-thiols ased on the nanoaggregates of a tetraphenylethenecoumarin fluorophoreNanoscale,2014,6,14691.

11.Ruixue Duan, Boya Wang,Fan Xia*, et al. “Sensitive and bidirectional detection of urine telomerase based on the four detection-color states of difunctional gold nanoparticle probe”Analytical Chemistry,2014,86,9781.

12.Yongmei Jia, Benmei Wei, Fan Xia*, et al.“Imparting biomolecules to a metal-organic framework material by controlled DNA tetrahedron encapsulation” Scientific Reports,2014,4,5929.

13.Fan Xia*and Xiaolei Zuo, “Sandwich assay for proteins, nucleic acids, small molecules and ions” Chemical Reviews,2014,114,7631.

14.Fan Xia*, Ruixue Duan, Xiaolei Zuo, et al. “Quadratic isothermal amplification for the detection of microRNA” Nature Protocols,2014,9, 597.

15.Yongmei Jia, Ruixue Duan, Fan Xia*, et al. “Electrochemical biocomputing: a new class of molecular-electronic logic devices” Soft matter,2013, 9, 6571.

16.Ruixue Duan, Xiaolei Zuo, Fan Xia*, et al. “Lab in a Tube: Ultrasensitive Detection of MicroRNAs at the Single-Cell Level and in Breast Cancer Patients Using Quadratic Isothermal Amplification” Journal of the American Chemical Society,2013,135,4604.

17.Nannan Liu, Yanan Jiang, Fan Xia*, et al. “Two-Way Nanopore Sensing of Sequence-Specific Oligonucleotides and Small-Molecule Targets in Complex Matrices Using Integrated DNA Supersandwich Structures” Angewandte Chemie-International Edition,2013, 52, 2007.

18.Yanan Jiang, Nannan Liu, Fan Xia*, et al. “Highly-Efficient Gating of Solid-State Nanochannels by DNA Supersandwich Structure Containing ATP Aptamers: A Nanofluidic IMPLICATION Logic Device” Journal of the American Chemical Society,2012,134,15395.

19.Di Kang, Ryan J. White,Fan Xia*, et al. “DNA biomolecular-electronic encoder and decoder devices constructed by multiplex biosensors” NPG Asia Materials,2012,4,15197.

20.Hongwei Xia, Fan Xia*, et al. “Tuning surface wettability through supramolecular interactions” Soft Matter,2011,7,1638.

21.Hongwei Xia, Fan Xia*, Yecang Tang, et al.“Tuning Surface Wettability through Supramolecular Interactions”Soft Matter,2011,7,1638.

22.Fan Xia,Xiaolei Zuo, Renqiang Yang, et al. “On the Binding of Cationic, Water-Soluble Conjugated Polymer to DNA:Electrostatic and Hydrophobic Interactions” Journal of the American Chemical Society,2010,132,1252.

23.Fan Xia, Xiaolei Zuo, Alexis Vallée-Bélisle, et al. “Colorimetric Detection of DNA Sequences, Small Molecules, Proteins and Ions, using Unmodified Gold Nanoparticles and Conjugated Polyelectrolytes” Proceedings of the National Academy of Sciences of the United States of America,2010,107,10837.

24.Fan Xia, Xiaolei Zuo, Yi Xiao, et al. “Label-free, Dual-analyte Electrochemical Biosensors: A New Class of Molecular-Electronic Logic Gates” Journal of the American Chemical Society,2010,132,8557.

25.Fan Xia, Ryan White, Xiaolei Zuo, et al. “An Electrochemical Supersandwich Assay for Sensitive and Selective DNA Detection in Complex Matrices” Journal of the American Chemical Society,2010,132,14346.

26.Fan Xia, Lin Feng and Lei Jiang “Smart responsive surfaces switching reversibly between super-hydrophobicity and super-hydrophilicity” Soft matter,2009, 5, 275.

27.Fan Xia, Wei Guo, Youdong Mao, et al. “Gating of single synthetic nanopores by proton-driven DNA molecular motors” Journal of the American Chemical Society,2008,130,8345.

28.Fan Xia and Lei Jiang “Bio-inspired smart multi-scale interfacial materials” Advanced Materials,2008, 20, 2842.

29.Fan Xia, Hui Ge, Yi Hou, et al. “Multiresponsive Surfaces Change Between Superhydrophilicity and Superhydrophobicity” Advanced Materials,2007,19,2520.

30.Fan Xia, Lin Feng, Shutao Wang, et al. “Dual-Responsive Surfaces That Switch between Superhydrophilicity and Superhydrophobicity” Advanced Materials,2006,18, 432.

 

获奖与荣誉

  1. 中组部“青年千人”计划(2012)
  2. 湖北省特聘专家(2012)
  3. 青年973首席科学家(2014)