华中科技大学化学与化工学院 华中科技大学化学与化工学院

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姓 名: 钟芳锐   ZHONG Fangrui
出生年月:1986-04
学历: 博士
职称: 教授
专业方向:有机合成,不对称催化
电 话:
Email:chemzfr@hust.edu.cn
个人主页:http://english.chem.hust.edu.cn/faculty/directory-detail/1606

教育与研究经历

2015.12年起     华中科技大学化学与化工学院(教授,博士生导师)

2013-2015        德国慕尼黑工业大学,洪堡学者、博士后研究员(导师:Thorsten Bach教授)

2008-2012        新加坡国立大学,有机化学博士(导师:Yixin LU教授)

2004-2008        浙江大学化学系,理学学士

研究领域与兴趣

研究领域为有机合成方法学,主要研究方向为不对称催化合成,包括新型手性催化剂、手性官能化配体的设计,复杂结构生物活性分子的快速构建,重点探索基于仿生理念,次级键诱导的有机小分子和过渡金属催化中的立体化学选择性。

已在国际学术期刊上发表论文29 篇,分别发表在J. Am. Chem. Soc.、Angew.Chem.Int.Ed.、Chem. Sci.、Org. Lett.等一流期刊上,其中影响因子>5的论文20篇,多篇被SYNFACTS等作亮点评论。论文被引用1300余次,单篇最高引用>200, H-因子18.

欢迎有志向感兴趣的同学加入本课题开展硕士或博士课题研究!同时也欢迎本科生同学来实验室开展科研训练!

教学情况

1. 留学生有机化学实验(英语)

2. 本科生和研究生《有机结构分析》

承担项目与课题

1. 华中科技大学人才引进基金,2016-2018,主持

2. 华中科技大学自主创新基金, 2016-2017,主持

3. 国家自然科学基金,2017-2019,项目批准号21602067,主持

代表性成果

1. Tianli Wang, Xiaoyu Han, Fangrui Zhong, Weijun Yao, Yixin Lu. "Amino acid-derived Bifunctional Phosphines for Enantioselective Transformations" Acc. Chem. Res., 2016, 49, 1369.

2. Fangrui Zhong, Alexander Pöthig, Thorsten Bach. “Synergistic Stereocontrol in the Enantioselective Ruthenium- catalyzed Sulfoxidation of Spirodithiolane-Indolones” Chem. Eur. J. 2015, 21, 10310.

3. Tianli Wang, Weijun Yao, Fangrui Zhong, Guohao Pang, Yixin Lu. “Phosphine-Catalyzed Enantioselective g-Addition of 3-Substituted Oxindoles to 2,3-Butadienoates and 2-Butynoates: Use of Prochiral Nucleophiles”, Angew. Chem. Int. Ed. 2014, 53, 2964.

4. Fangrui Zhong, Thorsten Bach. “Enantioselective Construction of 2,3-Dihydrofuro[2,3-b]quinolines through Supramolecular Hydrogen Bonding Interactions” Chem. Eur. J. 2014, 20, 13522.

5. Fangrui Zhong,Xiaowei Dou, Weijun Yao, Qiang Zhu, Yixin Lu.“Chiral Phosphine-Catalyzed Asymmetric Michael Addition of Oxindoles” Angew. Chem. Int.Ed. 2013, 52, 943.(highlighted in SYNFACTS2013, 216, times cited >45)

6. Jie Luo, Haifei Wang, Fangrui Zhong, Jacek, Kwiatkowski, Li-Wen Xu, Yixin Lu. “Highly diastereoselective and enantioselective direct Michael addition of phthalide derivatives to nitroolefins” Chem. Commun.2013, 49, 5775.

7. Xiaowei Dou, Bo Zhou, Weijun Yao, Fangrui Zhong, Chunhui Jiang, Yixin Lu. “A Facile and Versatile Approach for the Asymmetric Synthesis of Oxindoles with a 3-Sulfenyl -substituted Quaternary Stereocenter”. Org. Lett.2013, 15, 4920.

8. Fangrui Zhong,Jie Luo, Guo-Ying Chen, Xiaowei Dou, Yixin Lu. “Highly Enantioselective Regiodivergent Allylic Alkylations of MBH Adducts with Phthalides” J. Am. Chem. Soc. 2012, 134, 10222.(highlighted in SYNFACTS2012, 906, times cited >55)

9. Fangrui Zhong, Xiaoyu Han, Youqing Wang, Yixin Lu. “Highly Enantioselective [4 + 2] Annulations Catalyzed by Amino Acid-Based Phosphines: Synthesis of Functionalized Cyclohexenes and 3-Spirocyclohexene-2-oxindoles”,Chem. Sci. 2012, 3, 1231.(times cited >65)

10. Xiaoyu Han, Fangrui Zhong, Youqing Wang, Yixin Lu. “Versatile Enantioselective [3 + 2] Cyclization between Imines and Allenoates Catalyzed by Dipeptide-Based Phosphines”, Angew. Chem. Int. Ed. 2012, 51, 767. (times cited >65)

11. Jie Luo, Haifei Wang, Fangrui Zhong, Jacek Kwiatkowski, Li-Wen Xu, Yixin Lu. “Direct Asymmetric Mannich Reaction of Phthalides: Facile Access to Chiral Substituted Isoquinolines and Isoquinolinones”, Chem. Commun. 2012, 48, 4707.

12. Xiaowei Dou,Fangrui Zhong,Yixin Lu. “A Highly Enantioslective Synthesis of Functionalized 2,3-Dihydrofurans via a Modified Feist−Bénary Reaction” Chem. Eur. J. 2012, 18, 13945.

13. Guo-Ying Chen, Fangrui Zhong, Yixin Lu. “Asymmetric Allylic Alkylation of Isatin-derived Morita-Baylis-Hillman Carbonates with Nitroalkanes”, Org. Lett.2012, 14, 3955.

14. Fangrui Zhong,Weijun Yao, Xiaowei Dou, Yixin Lu. “Enantioselective Construction of 3-Hydroxy Oxindoles via Decarboxylative Addition of b-Ketoacids to Isatins” Org. Lett. 2012, 14, 4018.

15. Fangrui Zhong,Guoying Chen, Xiaoyu Han, Weijun Yao, Yixin Lu. “Asymmetric Construction of Functionalized Bicyclic imides via [3+2] Annulation of MBH Carbonates Catalyzed by Dipeptide-based Phosphines” Org. Lett. 2012, 14, 3764. (times cited >45)

16. Fangrui Zhong, Xiaoyu Han, Youqing Wang, Yixin Lu. “Highly Enantioselective [3+2] Annulation of Morita-Baylis-Hillman Adducts Mediated by L-Threonine Derived Bifunctional Phosphines: Creation of 3-Spirocyclopentene-2-oxindoles with Two Consecutive Quaternary Centers”, Angew. Chem. Int. Ed. 2011, 50, 7837. (highlighted in SYNFACTS2011, 1020, times cited >200)

17. Fangrui Zhong, Youqing Wang, Xiaoyu Han, Kuo-Wei Huang, Yixin Lu. “L-Threonine-Derived Bifunctional Phosphine-Sulfonamide Catalyst-Promoted Enantioselective Aza-Morita-Baylis-Hillman Reaction”, Org. Lett. 2011, 13, 1310. (highlighted in SYNFACTS 2011, 551, times cited >50)

18. Fangrui Zhong, Guo-Ying Chen, Yixin Lu. “Enantioselective Morita-Baylis-Hillman Reaction of Isatins with Acrylates: Facile Creation of 3-Hydroxy-2-Oxindoles”, Org. Lett. 2011, 13, 82. (times cited >80)

19. Xiaoyu Han, Youqing Wang, Fangrui Zhong, Yixin Lu. “Enantioselective [3 + 2] Cycloaddition of Allenes to Acrylates Catalyzed by Dipeptide-derived Novel Phosphines: Facile Creation of Functionalized Cyclopentenes Containing Quaternary Stereogenic Centers”, J. Am. Chem. Soc.2011, 133, 1726 (times cited >125).

20. Guo-Ying Chen, Fangrui Zhong, Yixin Lu. “Highly Enantioselective and Regiospecific Substitution of Morita-Baylis-Hillman Carbonates with Nitroalkanes” Org. Lett.2011, 13, 6070.

21. Xiao Han, Fangrui Zhong, Yixin Lu. “Highly Enantioselective Amination Reactions of Fluorinated Ketoesters Catalyzed by Novel Chiral Guanidines Derived from Cinchona Alkaloids”, Adv. Synth. Catal. 2010, 352, 2778.

获奖与荣誉

1. 2017 Thieme Chemistry Journal Award

2. 湖北省第七批百人计划入选者

3. 德国洪堡学者

4. 新加坡国立大学 Wang Gungwu Medal & Prize (2012优秀博士论文奖,全校遴选1人)

5. Singapore National Institute of Chemistry Gold Medal (2012优秀博士论文奖,新加坡每年仅1名)

6. 4th HOPE MEETING(新加坡五名代表之一,日本学术振兴会JSPS主办,东京筑波)

7. 2012年Reaxys Phd Prize finalist(全球化学博士生遴选45人)

8. 2011年国家优秀自费留学生奖学金

更多信息请浏览个人(或课题组)主页:http://english.chem.hust.edu.cn/faculty/directory-detail/1606