华中科技大学化学与化工学院 华中科技大学化学与化工学院

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姓 名: 吴钰周   wuyuzhou
出生年月:1985-05
学历: 博士
职称: 教授
专业方向:化学生物学,生物纳米材料
电 话:
Email:wuyuzhou@hust.edu.cn
个人主页:http://bionano.chem.hust.edu.cn/

教育与研究经历

教育经历:

2010-2013  德国乌尔姆大学化学系,博士 (summa cum laude)

2008-2010  新加坡国立大学化学系,硕士

2004-2008  浙江大学化学系,学士

工作经历:

2016年9月 至今 华中科技大学化学与化工学院,教授,博士生导师,

2016年9月 至今  德国马克思普朗克高分子研究所,课题组长(兼职)

2016年5月-2016年9月 德国马克思普朗克高分子研究所,课题组长,

2013-2016 德国乌尔姆大学,课题组长 (Habilitation)
 

研究领域与兴趣

研究领域:

智能生物纳米材料,纳米医药及靶向药物载体,复合高分子材料,DNA 折纸术

研究方向:

本课题组主要致力于以蛋白质及核酸等生物大分子为原料设计和制备智能生物纳米材料的研究。结合生物工程技术和化学合成技术的手段对天然蛋白质及核酸进行改造,设计和诱导其有序的自组装过程,同时研究生物大分子与合成高分子的复合材料,设计和制备能够用于纳米医药,靶向药物传递,生物成像,癌症诊疗等领域的新型智能纳米材料。

教学情况


承担项目与课题

2016-2019,欧盟Horizon 2020 – Hyperdiamond: The Diamond Revolution in Hyperpolarized MR Imaging – Novel Platform and Nanoparticle Targeted Probe. 子课题主持,项目经费€ 400,000,

2014-2017,德国Baden-Württemberg Stiftung BioMatS-15: Protein-DNA Hybrid Hydrogels as Sustainable Materials for Tissue Engineering. 主持,项目经费€ 340,000,

2014-2016,德国Volkswagen Stiftung: Engineering binding cavities and surface amphiphilicity at the molecular scale for efficient in vivo drug delivery. 参与,项目经费€194,400

2013-2019,欧盟ERC Synergy grant: Diamond quantum devices and biology. 参与,项目经费€ 357,6960

学术兼职

Annals of Chemistry Editorial Board

Plos One, Scientific Reports等期刊审稿人

代表性成果

1.       Yu Tokura, Yanyan Jiang, Alexander Welle,Martina H Stenzel, Katarzyna Krzemien, Jens Michaelis, Christopher Barner-Kowollik, Yuzhou Wu*,Tanja Weil*,Bottom-up Fabrication of Nanopatterned Polymers on DNA Origami Nanotile by In-situ Atom Transfer Radical Polymerization, Angew. Chem. Int. Ed., 2016,55, 5692-5697. (Frontispiece)

2.       Yuzhou Wu*, Fedor Jelezko, Martin Plenio, Tanja Weil*, Diamond Quantum Sensing in Biology,Angew. Chem. Int. Ed., 2016,55, 6586-6598.

3.       David Palesch, Felix Boldt, Janis A. Müller, Klaus Eisele, Christina M. Stürzel, Yuzhou Wu*, Jan Münch*, Tanja Weil*. PEGylated cationic serum albumin to boost retroviral gene transfer. ChemBioChem, 2016, DOI: 10.1002/cbic.201600193.  2.85

4.       Felix Boldt, Weina Liu, Yuzhou Wu*, Tanja Weil*. Converting Human Proteins into Precision Polymer Therapeutics. Curr Pharm Des., 2016, 22, 2866-2872.  3.052

5.       Tao Wang, Andreas Riegger, Markus Lamla, Sebastian Wiese, Patrick Oeckl, Markus Otto, Yuzhou Wu, Stephan Fischer, Holger Barth, Seah Ling Kuan and Tanja Weil*, Water-soluble allyl sulfones for dual site-specific labelling of proteins and cyclic peptides, Chem. Sci., 2016, 7, 3234-3239

6.       Seah Ling Kuan, Christina Förtsch, David Y. W. Ng, Stephan Fischer, Yu Tokura, Weina Liu, Yuzhou Wu, Kaloian Koynov, Holger Barth and Tanja Weil1*, A supramolecular approach toward bioinspired PAMAM-dendronized fusion toxins, 2016, Macromol. Biosci. DOI: 10.1002/mabi.201500417

7.       Christiane Seidler, David. Y. W. Ng,Yuzhou Wu and Tanja Weil*, pH responsive supramolecular core-shell protein hybrids, Supramolecular Chemistry, 2016, DOI:10.1080/10610278.2016.1140764

8.       Sylvia Schmid,* David. Y. W. Ng, Elena. Mena-Osteritz, Yuzhou Wu, Tanja Weiland Peter Bäuerle, Self-assembling oligothiophene–bolaamphiphiles for loading and controlled release of doxorubicin into living cells. Chem. Commun., 2016, 52, 3235-3238.

9.       Yuzhou Wu*, Anna Ermakova, Weina Liu, Goutam Pramanik, Minh Vu, Andrea Kurz, Liam McGuinness, Boris Naydenov, Susanne Hafner, Rolf Reuter, Joerg Wrachtrup, Dominique Böcking, Junichi Isoya, Thomas Simmet, Fedor Jelezko*, Tanja Weil*, Programmable Biopolymers for Advancing Biomedical Applications of Fluorescent Nanodiamonds, Adv. Funct. Mater., 2015, 25, 6576–6585.

10.    Yuzhou Wu, David Yuen Wah Ng, Seah Ling Kuan, Tanja Weil*, “Protein-Polymer Therapeutics – A Macromolecular Perspective”, Biomaterials Science, 2015, 3, 214-230.  3.614

11.    René Stangenberg#, Yuzhou Wu#, Seah Ling Kuan, Dennis Kurzbach, Dariush Hinderberger, Jana Hedrich, Malin Insa Preiß, Heiko J. Luhmann, Tanja Weil* and Klaus Müllen*, “A Polyphenylene Dendrimer Drug Transporter with Precisely Positioned Amphiphilic Surface Patches”,Adv. Healthcare Mater.,2015, 4, 377-384. (#Shared first authorship).

12.    Tao Zhang, Andre Neumann, Jessica Lindlau, Yuzhou Wu, Goutam Pramanik, Boris Naydenov, Fedor Jelezko, Florian Schüder, Sebastian Huber, Marinus Huber, Florian Stehr, Alexander Högele*, Tanja Weil* and Tim Liedl*, DNA-based self-assembly of fluorescent nanodiamonds, J. Am. Chem. Soc.,2015, 31, 9776–9779.

13.    Tao Wang, Yuzhou Wu, Seah Ling Kuan, Oliver Dumele, Markus Lamla, David Y. W. Ng, Matthias Arzt, Jessica Thomas, Jan. O. Mueller, Christopher Barner-Kowollik*, Tanja Weil*, A Disulfide Intercalator Toolbox for Site-Directed Polypeptide Modification, Chemistry – a European Journal, 2015, 21, 228-238.

14.    Tao Wang, Natalia Zabarska, Yuzhou Wu, MarkusLamla, Stephan Fischer, Katharina Monczak, David Y. W.Ng,* SvenRau* and TanjaWeil*, Receptor Selective Ruthenium-Somatostatin Photosensitizer for Cancer Targeted Photodynamic Applications, Chem. Commun.2015, 51, 12552-12555.

15.    Yuzhou Wu*, Chuang Li, Felix Boldt, Christina Förtsch, Holger Barth, Yanran Wang, Seah Ling Kuan, Thuy Tam Tran, Viktoria Mikhalevich, Zhongqiang Yang, Dongsheng Liu*, Tanja Weil*, “Programmable protein–DNA hybrid hydrogels for the immobilization and release of functional proteins”, Chem. Comm., 2014, 50, 14620-14622.

16.    David Yuen Wah Ng#, Yuzhou Wu#, Seah Ling Kuan and Tanja Weil*, “Programming Supramolecular Biohybrids as Precision Therapeutics”, Acc. Chem. Res., 2014, 47, 3471-3480. (#Shared first authorship).

17.    Chuang Li, Ping Chen, Yu Shao, Xu Zhou, Yuzhou Wu, Zhongqiang Yang, Zhibo Li, Tanja Weil, Dongsheng Liu*, “A writable polypeptide-DNA hydrogel with rationally designed multi-modification sites”, Small, 2014,11, 1138-1143.

18.    Tao Wang, David Y. W. Ng, Yuzhou Wu, Jessica Thomas, Thuy TamTran and Tanja Weil*. “Bis-sulfide bioconjugates for glutathione triggered tumor responsive drug release” Chem. Commun., 2014, 50, 1116-1118.

19.    David Y. W. Ng, Matthias Arzt, Yuzhou Wu, Seah Ling Kuan, Markus Lamla, Tanja Weil*. “Constructing Hybrid Protein Zymogens through Protective Dendritic Assembly” Angew. Chem. Int. Ed. 201453, 324-328.

20.    Christoph Meier, Yuzhou Wu, Goutam Pramanik, Tanja Weil*. “Self-?Assembly of High Molecular Weight Polypeptide Copolymers Studied via Diffusion Limited Aggregation” Biomacromolecules2014, 15, 219-227.

21.    David Yuen Wah Ng, Jörg Fahrer, Yuzhou Wu, Klaus Eisele, Seah Ling Kuan, Holger Barth*, Tanja Weil*. “Efficient Delivery of p53 and Cytochrome C by Supramolecular Assembly of a Dendritic Multi-Domain Delivery System” Adv. Healthcare Mater. 2014, 2, 1620-1629.

22.    Yuzhou Wu, Susann Ihme, Michaela Feuring-Buske, Seah Ling Kuan, Klaus Eisele, Markus Lamla, Yanran Wang, Christian Buske, and Tanja Weil*. “A Core-shell Albumin Copolymer Nanotransporter for High Capacity Loading and Two-step Release of Doxorubicin with Enhanced Anti-leukemia Activity”Adv. Healthcare Mater., 2013, 2, 884-894.

23.    Diego Pesce#, Yuzhou Wu#, Anke Kolbe, Tanja Weil* and Andreas Herrmann*. “Enhancing Cellular Uptake of GFP via Unfolded Supercharged Protein Tags” Biomaterials, 2013, 34, 4360. (#Shared first authorship).

24.    Seah Ling Kuan, David Y. W. Ng, Yuzhou Wu, Christina Förtsch, Holger Barth, Mikheil Doroshenko, Kaloian Koynov, Christoph Meier, Tanja Weil*. J. Am. Chem. Soc. 2013, 135, 17254.

25.    Jana Hedrich, Yuzhou Wu, Seah Ling Kuan, Frauke Kuehn, Eweline Pietrowski, Mike Sahl, Sandra Muth, Klaus Müllen, Heiko J. Luhmann, Tanja Weil, Manfred Schmidt. “Polymer Complexes in Biological Applications” Adv. Polym. Sci.2013, doi: 10.1007/12_2013_229. (Book Chapter).

26.    Tao Wang, Anne Pfisterer, Seah Ling Kuan, Yuzhou Wu, Oliver Dumele, Markus Lamla, Klaus Müllen and Tanja Weil*.“A Versatile and Orthogonal Approach for the Cross-Conjugation of DNA, Proteins and Peptides via the pH Switch”Chem. Sci., 2013, 4, 1889-1894.

27.    Seah Ling Kuan, Yuzhou Wu, Tanja Weil*. “Precision Biopolymers from Protein Precursors for Biomedical Applications”MacromolRapid Commun., 2013,34, 380.

28.    Seah Ling Kuan, Bettina Stöckle, David Y.W. Ng, Yuzhou Wu, Mikheil Doroshenko, Jörg Reichenwallner, Kaloian Koynov, Dariush Hinderberger, Klaus Müllen and Tanja Weil*. “Dendronized Albumin Biohybrids as Efficient Core-Shell Doxorubicin Delivery Systems”Biomacromolecules, 2013, 14 (2): 367–376.

29.    Yuzhou Wu, Klaus Eisele, Mikheil Doroshenko, Gerardo Algara-Siller, Ute Kaiser, Kaloian Koynov, Tanja Weil*. “A Quantum Dot Photoswitch for DNA Detection, Gene Transfection, and Live-Cell Imaging”Small, 2012, 8(22): 3465–3475.(Cover article)

30.    Yuzhou Wu, Goutam Pramanik, Klaus Eisele, Tanja Weil*.“Convenient Approach to Polypeptide Copolymers Derived from Native Proteins”Biomacromolecules, 2012, 13(6):1890-1898.

31.    Yuzhou Wu, Tao Wang, David Y.W. Ng, Tanja Weil*. “Multifunctional Polypeptide-PEO Nanoreactors via the Hydrophobic Switch”Macromol. Rapid Commun., 2012, 33(17):1474-1481.

32.    Yuzhou Wu,Tanja Weil*. “An Efficient Approach for Preparing Giant Polypeptide Triblock Copolymers by Protein Dimerization”Macromol. Rapid Commun., 2012, 33(15):1304-1309.

33.    Yuzhou Wu, Kai Shih Er, Arvind Ramanathan, Subhash Vasudevan, Tanja Weil*. “Nano-sized Albumin-copolymer Micelles for Efficient Doxorubicin Delivery”Biointerphases. 2012, 7(1-4):5.

34.    Yasar Akdogan, Yuzhou Wu, Klaus Eisele, Manuela Schaz, Tanja Weil* and Dariush Hinderberger*.“Host-Guest Interactions in Polycationic Human Serum Albumin Bioconjugates”Soft Matter, 2012, 8(43): 11106-11114.

35.    Yuzhou Wu, Sabyasachi Chakrabortty, Radu A. Gropeanu,Joerg Wilhelmi,Yang Xu, Kai Shih Er, Seah Ling Kuan, Kaloian Koynov, Yinthai Chan* and Tanja Weil*. “pH-Responsive Quantum Dots via an Albumin Polymer Surface Coating”J. Am. Chem. Soc., 2010, 132(14):5012-5014.

获奖与荣誉

2017     中组部第十三批青年千人计划

2015      Forschungsboni der Ulmer Universitätsgesellschaft (Ulm University)

2014      Promotionspreis der Ulmer Universitätsgesellschaft (Ulm University)

2013      Finalist of 2013 Reaxys PhD Prize

2013      Finalist of the Lanxess Talent award

2012      国家自费留学生奖学金

2008-2010   Research Scholarship (National University of Singapore, Singapore).

2008      浙江省优秀毕业生

2006-2007   Fung Scholarship (Fung Foundation, Hong Kong).

更多信息请浏览个人(或课题组)主页:http://bionano.chem.hust.edu.cn/