华中科技大学化学与化工学院 华中科技大学化学与化工学院

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姓 名: 龚跃法   Gong Yuefa
出生年月:1964-09
学历: 博士、教授
职称: 教授
专业方向:有机化学
电 话:027-87543232
Email:gongyf@mail.hust.edu.cn
个人主页:http://orglab.chem.hust.edu.cn/

教育与研究经历

1979-1983年在杭州大学化学系学习,获学士学位。1983-1988年在中科院上海有机化学研究所学习,从事有机化学专业方面的研究工作,获得理学硕士及理学博士学位。

1988年底至今一直在华中科技大学化学系工作。期间1990-1992年在日本筑波大学化学系做博士后研究。1998-2002年以日本通产省特别研究员身份在日本工业技术院名古屋工业研究所做访问研究。

研究领域与兴趣

科研领域与兴趣:

1)有机合成方法学  2)  自由基化学   3)含氟生物活性分子的设计合成   4)杂环化合物的构建   5)不对称催化合成


 

教学情况

在华中科技大学化学系工作期间,先后承担了本科生的《有机化学》、《有机化学实验》、《有机合成》和《有机波谱学》等课程的教学;以及研究生的《高等有机化学》和《有机化学前沿》等课程的教学。湖北省精品课程《有机化学》负责人。

承担项目与课题

国家自然科学基金面上项目:

1. 基于1-卤代环丙基甲酸酯构建结构多样化环状骨架的新反应体系研究 21472053

2. 氟离子诱导卤代缺电子烯烃与亲电试剂间的交叉反应研究 21172082

3. 烯键还原酶催化共轭烯醛的不对称反应研究 20872041

4. 化学-生物接力催化合成手性胺基伯醇的研究 20572028

学术兼职

湖北省化学化工协会理事

代表性成果

教材专著:《有机化学》、《合成化学》等

 

 代表性论文:

1.  Triflic Acid-Catalyzed Cycloisomerization Reactions of Donor−Acceptor Cyclopropanes: Access to Alkyl 5?Arylfuran-2-carboxylates

Yuequan Zhu, Panpan Xu, and Yuefa Gong*

The Journal of Organic Chemistry  2016,  81,  4829−4834

2.  Direct Construction of the 9H-Pyrrolo[1,2-a]azepin-9-amine Skeleton via [4+3] Annulation of Alkyl 2-Aroyl-1-chlorocyclo- propanecarboxylates

Hu, Junhao; Liu, Yang; Gong, Yuefa*

Advanced Synthesis & Catalysis  2015, 357(13), 2781-2787.  Cover paper

3.  Cycloaddition Reactions of Alkyl Cyclopropenecarboxylates Generated in situ with Nitrones: Construction of Substituted Pyrroles and 1,2-Oxazinanes

Hu, Junhao; Zhang, Min; Gong, Yuefa*

European Journal of Organic Chemistry  2015(9), 1970-1978. 

4.  Construction of 2-Pyrone Skeleton via Domino Sequence between  2-Acyl-1-Chlorocyclo- propanecarboxylate and Amines

Zhu, Yuequan; Gong, Yuefa*

The Journal of Organic Chemistry  2015,  80(1), 490-498. 

5.  Synthesis of functionalized fulvenes: [3+2] annulation of ethyl α-chlorocyclopropaneformates with 1,3-dicarbonyl compounds

Zhu, Yuequan; Zhang, Min; Yuan, Hongling; Gong, Yuefa*

Organic & Biomolecular Chemistry  2014, 12(44), 8828-8831.

6.  Stereoselective Cascade Formal Nucleophilic Substitution and Mannich Reaction of Ethyl 2-Aroyl-1-chlorocyclopropanecarboxylates

Zhang, Min; Luo, Fan; Gong, Yuefa*

The Journal of Organic Chemistry  2014, 79(3), 1335-1343. 

7.  Rhodium-Catalyzed Intramolecular Difluoromethylenative Dearomatization of Phenols.

Li, Yajun; Zhang, Lisi; Zhang, Li; Wu, Yongming*; Gong, Yuefa*

European Journal of Organic Chemistry  2013(35), 8039-8047.  

8.  A Two-Step Sequence to Ethyl α-Fluorocyclopropanecarboxylates Through MIRC Reaction of Ethyl Dichloroacetate and Highly Regioselective Fluorination

Zhang, Min; Gong, Yuefa*; Wang, Weizhou

European Journal of Organic Chemistry  2013(32), 7372-7381.

9.  Copper-Catalyzed Enantioselective Henry Reaction of Enals and Subsequent Iodocyclization: Stereoselective Construction of Chiral Azatricyclic Frameworks

Zhou, Yirong; Zhu, Yuequan; Yan, Shaobai; Gong, Yuefa*

Angewandte Chemie, International Edition  2013, 52(39), 10265-10269.

10. Synthesis of Fluorine-Containing Multisubstituted Phenanthridines by Rhodium-Catalyzed Alkyne [2+2+2] Cycloaddition and Tandem sp2 C-H Difluoromethylenation

Li, Yajun; Zhu, Jiangtao; Zhang, Lisi; Wu, Yongming*; Gong, Yuefa*

Chemistry - A European Journal  2013, 19(25), 8294-8299.

11. Camphor-derived C1-symmetric chiral diamine organocatalysts for asymmetric Michael addition of nitroalkanes to enones.

Zhou, Yirong; Liu, Qiang;Gong, Yuefa*

Organic & Biomolecular Chemistry  2012, 10(37), 7618-7627.

12. Rh-catalyzed intramolecular sp2 C-H bond difluoromethylenation.

Li, Yajun; Zhu, Jiangtao; Xie, Haibo; Li, Shan; Peng, Dongjie; Li, Zhengke; Wu, Yongming*; Gong, Yuefa*.

Chemical Communications  (2012),  48(25),  3136-3138. 

13. A highly chemo- and enantioselective nitroaldol reaction of haloenals: preparation of chiral functionalized allylic alcohols

Gu, Lianghu; Zhou, Yirong; Zhang, Jingli; Gong, Yuefa*

Tetrahedron: Asymmetry (2012), 23(2), 124-129.

14. Copper(II)-Catalyzed Asymmetric Henry Reaction of o-Alkynylbenzaldehydes Followed by Gold(I)-Mediated Cycloisomerization: An Enantioselective Route to Chiral 1H-Isochromenes and 1,3-Dihydroisobenzofurans. 

Lu, Deng-Fu; Zhou, Yi-Rong; Li, Ya-Jun; Yan, Shao-Bai; Gong, Yue-Fa*.     

The Journal of Organic Chemistry  2011,  76(21),  8869-8878. 

15. Enantioselective bioreduction of 2-fluoro-2-alken-1-ols mediated by Saccharomyces cerevisiae. 

Luo, Fan; Lu, Dengfu; Gong, Yuefa*.   

Journal of Molecular Catalysis B: Enzymatic  2011,  70(3-4),  101-107.

16. Cross-coupling reactions of two different activated alkenes through tetrabutylammonium fluoride (TBAF) promoted deprotonation/activation strategy: a regioselective construction of quaternary carbon centers. 

Zhang, Jing-Li; Gong, Yue-Fa*.     

Organic Letters  2011,  13(2),  176-179. 

17.  Synthesis of C1-Symmetric Chiral Secondary Diamines and Their Applications in the Asymmetric Copper(II)-Catalyzed Henry (Nitroaldol) Reactions.

Zhou, Yirong; Dong, Junfang; Zhang, Fanglin; Gong, Yuefa*.     

The Journal of Organic Chemistry  2011,  76(2),  588-600. 

18. Organocatalytic Asymmetric Tandem Michael Addition-Hemiacetalization: A Route to Chiral Dihydrocoumarins, Chromanes, and 4H-Chromenes.

Lu, Dengfu; Li, Yajun; Gong, Yuefa*.      

The Journal of Organic Chemistry  2010,  75(20),  6900-6907.

19. Prolylprolinol-Catalyzed Asymmetric Michael Addition of Aliphatic Aldehydes to Nitroalkenes. 

Lu, Dengfu; Gong, Yuefa*; Wang, Weizhou.     

Advanced Synthesis & Catalysis  2010,  352(4),  644-650.

20. Asymmetric Organocatalytic Four-Component Quadruple Domino Reaction Initiated by Oxa-Michael Addition of Alcohols to Acrolein.

Zhang, Fang-Lin; Xu, Ai-Wen; Gong, Yue-Fa*; Wei, Mo-Hui; Yang, Xiang-Liang.     Chemistry--A European Journal  2009)  15(28),  6815-6818.

获奖与荣誉

《单电子转移反应的化学及顺磁共振研究》获国家教委科技进步二等奖(甲类) ,1993。
 

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