华中科技大学化学与化工学院 华中科技大学化学与化工学院

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姓 名: 黄开勋   HKX
出生年月:1954-11
学历: 博士
职称: 教授
专业方向:生物无机化学
电 话:
Email:hxxzrf@hust.edu.cn
个人主页:

教育与研究经历

1982年1月武汉大学化学系毕业获学士学位,1987年6月和1995年6月分别于华中理工大学化学系和生物系研究生毕业,获硕士和博士学位。1992年-1993年丹麦Roskilde大学生命科学与化学学院合作研究;2000年意大利Padova大学生物化学系及2001年-2002年英国Surrey大学生物医学与生命学院高级访问学者。

研究领域与兴趣

(1)硒蛋白的生物学功能,着重于硒蛋白在糖尿病、血管疾病和白内障发生发展中作用及机理;

(2)新药制剂及功能食品的研究与开发;

(3)无机纳米材料的合成与生物安全性研究。

教学情况

本科生教学:《基础化学》、《生命科学导论》、《无机化学》

研究生教学:《蛋白质与核酸的化学》、《生物无机化学》、《高等无机化学》

承担项目与课题

l  近年来承担的纵向项目:

(1)国家自然科学基金项目

——硒和活性氮对胰岛素信号传导系统的调控作用及机理(20671037):

——Sep15 对晶状体细胞分化紊乱的抑制机理和防障作用(21271077)

——硒蛋白R 在眼晶状体中的生物学功能及作用机理(30870555)

——硒和活性氮对胰岛素信号传导系统的调控作用及机理(20671037)

——硝基化对胰岛素及其受体结构、功能的影响及硒的抑制作用的研究(20371018)

——新的血管硒蛋白的纯化、表征及生物功能研究(29971012)

(2)博士点基金:RNA 干扰技术对硒蛋白S 与胰岛素抵抗关系的研究

(3)973项目子课题(2006CB705606A):纳米材料TiO2安全性解决方案的探索;

(4)新药研制:①降钙素口腔喷雾剂的临床前研究(中外合作项目);

                              ②国家863重大专项:胰岛素口腔喷雾剂的研制

学术兼职

——国家食品药品监督管理局保健食品评审专家;

——教育部第四、五届科技委化学化工学部委员;

——中国化学会理事、湖北省化学化工学会副理事长;

——湖北省硒资源开发与利用促进会理事长;

——‘International Symposium on Selenium in Biology and Medicine’(国际硒的生物医学研讨会)International Scientific and Programme Organizing Committee成员;

——‘The International Journal of Molecular Sciences’ (ISSN 1422-0067) Editorial Board成员;

——主持召开第一、第二届中韩双边硒的生物医学研讨会(国家自然科学基金31181340307、21281240354支持);

——作为副主席主持承办TEMA14(第14届人与动物国际学术研讨会)。

代表性成果

      在国际学术期刊发表SCI论文100余篇,作为合作主编出版有硒的专著1本,参编专著3本。其中,近5年发表的代表性论文如下:

  1. Hongjie Chen, Weiqun Tian, Kaixun Huang*. Effect of blood-retinal barrier development on formation of selenite nuclear cataract in rat. Toxicology Letters. 216 (2013): 181-188.
  2. Yi Li, Yi Ji, Jun Zhou, Kaixun Huang*. Effect of methionine sulfoxide reductase B1 silencing on high-glucose-induced apoptosis of human lens epithelial cells. Life Sciences.92(2013): 193-201
  3. HA Abbood, KAM Ahmed, Y Ren, KX Huang*. MnV2O6?V2O5 cross-like nanobelt arrays: synthesis, characterization and photocatalytic properties. Appl Phys A. (2013) 112: 901-909
  4. Y Jia, Y Li, SQ Du, KX Huang*. Involvement of MsrB1 in the regulation of redox balance and inhibition of peroxynitrite-induced apoptosis in human lens epithelial cells. Experimental Eye Research 100 (2012): 7-16.
  5. Hayder A. Abbood, H Peng, XH Gao, BE Tan, KX Huang*. Fabrication of cross-like NH4V4O10 nanobelt array controlled by CMC as soft template and photocatalytic activity of its calcinated product. Chemical Engineering Journal 209 (2012): 245-254.
  6. Khalid AM Ahmed, Hayder A. Abbood, KX Huang*. Hydrothermal synthesis of Mn(OH)O nanowires and their thermal conversion to (1D)-manganese oxides nanostructures. Journal of Crystal Growth. 2012, 358: 33-37.
  7. Khalid Abdelazez Mohamed Ahmed, Kaixun Huang*. Synthesis, characterization and catalytic activity of birnessite type potassium manganese oxide nanotubes and nanorods. Materials Chemistry and Physics 133 (2012) 605-610.
  8. Yi Li, Wen Zhang, Peiwu Li, Kaixun Huang*. Effect of streptozocin-induced diabetes mellitus on expression of methionine sulfoxide reductases and accumulation of their substrates in mouse lenses. Experim Eye Res. 92 (2011) 401-407
  9. Khalid Abdelazez Mohamed Ahmed, Hong Peng, Kangbing Wu, Kaixun Huang*. Hydrothermal preparation of nanostructured manganese oxides (MnOx) and their electrochemical and photocatalytic properties. Chemical Engineering Journal 172 (2011) 531-539
  10. Du SQ, Zhou J, Jia Y, Huang KX* SelK is a novel ER stress-regulated protein and protects HepG2 cells from ER stress agent-induced apoptosis. Arch Biochem Biophys. 2010, 502: 137-143
  11. Du SQ, Liu HM, Huang KX*. Influence of SelS gene silence on β-Mercaptoethanol- mediated endoplasmic reticulum stress and cell apoptosis in HepG2 cells. Biochim Biophys Acta. 2010, 1800: 511-517.
  12. Jun Zhou, Kaixun Huang*. Peroxynitrite mediates muscle insulin resistance in mice via nitration of IRβ/IRS-1 and Akt. Toxicology and Applied Pharmacology 2009, 241: 101-110
  13. Zeng, JH, Zhou, J, Huang, KX. Effect of selenium on pancreatic proinflammatory cytokines in streptozotocin-induced diabetic mice. Journal of Nutritional Biochemistry 2009, 20: 530-536
  14. Jun Zhou, Xingmu He, Kaixun Huang*. Bidirectional regulation of insulin receptor autophosphorylation and kinase activity by peroxynitrite. Archives of Biochemistry and Biophysics. 2009, 488: 1-8
  15. Liu HM, Wang TB, Huang KX*. Cholestiane-3 beta,5 alpha,6 beta-triol-induced reactive oxygen species production promotes mitochondrial dysfunction in isolated mice liver mitochondria. Chemico-Biological Interactions, 2009, 179 (2-3): 81-87
  16. Khalid Abdelazez Mohamed Ahmed, Qiumei Zeng, Kangbing Wua, Kaixun Huang*. Mn3O4 nanoplates and nanoparticles: Synthesis, characterization, electrochemical and catalytic roperties, Journal of Solid State Chemistry, 2010, 183(3): 744-751
  17. Jun Zhou, Haidong Li, Jinhong Zeng, Kaixun Huang*. Effects of peroxynitrite-induced protein tyrosine nitration on insulin-stimulated tyrosine phosphorylation in HepG2 cells. Mol Cell Biochem, 2009, 331:49-57
  18. Xue G, Liu FX, Wang Y, Huang KX*. Optimization of Synthetic Conditions for the Preparation of Dihomo-gamma-Linolenic Acid from gamma-Linolenic Acid Journal of the American Oil Chemists Society, 2009, 86 (1): 77-82
  19. Cheng GE, Huang T, Wu K, Huang KX*. Synthesis of Fiber-Like Porous Microstructures SnO2 Templated by Cotton Fibers and Their Gas Sensing Properties Journal of Nanoscience and Nanotechnology, 2009, 9(3): 2001-2007
  20. Zhao PT, Zeng QM, Huang KX. Fabrication of beta-NiS hollow sphere consisting of nanoflakes via a hydrothermal process Materials Letters, 2009, 63 (2): 313-315
  21. Yu Zhang, Kaixun Huang*. DFT studies on the role of glutamate residue in the tyrosine nitration. Journal of Molecular Structure: THEOCHEM. 2008, 864(1-3): 48-55
  22. Jinhong Zeng, Shaoqing Du, Jun Zhou, Kaixun Huang*. Role of SelS in lipopolysaccharide- induced inflammatory response in hepatoma HepG2 cells. Archives of Biochemistry and Biophysics, 2008, 478: 1–6
  23. Guoe Cheng, Tao Huang, Kui Wu and Kaixun Huang*. Synthesis of Fiber-Like Porous Microstructures SnO2 Templated by Cotton Fibers and Their Gas Sensing Properties. Journal of Nanoscience and Nanotechnology, 2008, 8, 1-7
  24. Pingtang Zhao, Qiumei Zeng, Xianliang He, Hao Tang, Kaixun Huang*. Preparation of γ-MnS hollow spheres consisting of cones by a hydrothermal method. Journal of Crystal Growth, 2008, 310: 4268–4272
  25. Liu HM, Liu SX, Huang KX*. Low-temperature chemical route to bismuth-doped tellurium single-crystalline nanorods. Materials Letters, 2008, 62(12-13): 1983-1985
  26. Pingtang Zhao and Kaixun Huang*. Preparation and Characterization of Netted Sphere-like CdS Nanostructures. Crystal Growth & Design. 2008, 8(2): 717–722
  27. Pingtang Zhao, Jinmin Wang, Guoe Chen, Zhou Xiao, Jing Zhou, Dean Chen, and Kaixun Huang*. Hydrothermal Synthesis of PbS Hollow Spheres with Single Crystal-Like Electron Diffraction Patterns. Journal of Nanoscience and Nanotechnology. 2008, 8: 379-385