华中科技大学化学与化工学院 华中科技大学化学与化工学院

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姓 名: 刘红梅   liuhongmei
出生年月:
学历: 博士研究生
职称: 教授
专业方向:生物无机化学;无机固体化学
电 话:
Email:hmliu2004@126.com
个人主页:

教育与研究经历

一、教育背景 
2001,9-2004,6
博士,化学生物学专业,北京大学医学部 
1998,9-2001,6
硕士,无机化学专业,华中科技大学 
1994,9-1998,6
学士,应用化学专业,华中科技大学
 
二、工作简历 
2004,7-2006,10
华中科技大学化学系,讲师 
2006,11-2011.10
华中科技大学化学与化工学院,副教授 
2011,11-至今华中科技大学化学与化工学院,教授

研究领域与兴趣

主要从事生物无机化学方向的科研工作,研究硒与重大疾病的关系及预防机制、硒蛋白的生物功能及与疾病的关系。近些年开始从事一些无机固体化学方面的研究,主要合成一些无机纳米材料并寻求其在生命科学中的应用。

教学情况

本科生教学: 《生物化学》、《无机化学》、《无机化学实验》、《生物无机化学》 
研究生教学:《细胞无机化学》(硕士生)

承担项目与课题

(1) 国家自然科学基金(编号:21771068):纳米硒抗动脉粥样硬化活性及分子机制研究

(2)  武汉市青年科技晨光计划(编号:2015070404010184):纳米硒加强他汀抗动脉粥样硬化的作用及机理研究

(3)  湖北省杰出青年基金(编号:2014CFA022):硒蛋白S 抑制动脉粥样硬化的作用及机理(4)  国家自然科学基金(编号:31170775):硒蛋白对血管钙化发生、发展的调节作用及机理研究

(5) 国家自然科学基金(编号:30700136):活性氧促进血管平滑肌细胞向成骨细胞分化的信号转导机制及硒的抑制作用

(6) 国家自然科学基金重点项目(编号:20637010)“稀土元素的生物化学反应和有关细胞化学过程的干预部分课题

(7)  湖北省自然科学基金(编号:2005ABA183):硒预防骨质疏松疾病的作用机理研究 

(8) 华中科技大学自主创新基金

学术兼职

中国微量元素科学研究会理事

中国微量元素科学研究会硒专业委员会委员

代表性成果

    1. 1.      Hongmei Liu, Huibi Xu and Kaixun Huang*, Selenium in the prevention of atherosclerosis and its underlying mechanisms, Metallomics, 2017, 9: 21-37

      2.      Leilei Guo, Long Mao, Kaixun Huang, and Hongmei Liu*. Pt–Se nanostructures with oxidase-like activity and their application in a selective colorimetric assay for mercury (II). J Mater Sci 2017, 52:10738–10750

      3.      Leilei Guo, Kaixun Huang, Hongmei Liu*. Biocompatibility selenium nanoparticles with an intrinsic oxidase-like activity. J Nanopart Res 2016, 18:74

      4.      Yali Ye, Fen Fu, Xiaoming Li, Jie Yang, Hongmei Liu*. Selenoprotein S is highly expressed in the blood vessels and prevents vascular smooth muscle cells from apoptosis. Journal of Cellular Biochemistry 2016,117:106-117

      5.      Jie Dai, Hongmei Liu, Jun Zhou and Kaixun Huang *. Selenoprotein R Protects Human Lens Epithelial Cells against D-Galactose-Induced Apoptosis by Regulating Oxidative Stress and Endoplasmic Reticulum Stress. Int. J. Mol. Sci. 2016, 17, 231

      6.      Hongmei Liu*, Shengqing Wang, Falong Jia. Conversion of commercial Pt/C to “clean” Pt-Cu/C catalyst with high activity toward methanol oxidation. Electrochimica Acta, 2015, 184:331-337

      7.      Na Yin, Xiaoxiang Zheng, Jun Zhou, Hongmei Liu, Kaixun Huang*. Knockdown of 15-kDa selenoprotein (Sep15) increases hLE cells’ susceptibility to tunicamycin-induced apoptosis. Journal of Biological Inorganic Chemistry, 2015, 20(8):1307-1317

      8.      刘红梅, 黄开勋*, 徐辉碧. 内质网硒蛋白的研究进展. 中国科学化学2014; 44(4): 531-540

      9.      Liu HM*, Li XM, Qin F, Huang KX. Selenium suppresses oxidative-stress-enhanced vascular smooth muscle cell calcification by inhibiting the activation of the PI3K/AKT and ERK signaling pathways and endoplasmic reticulum stress. Journal of Biological Inorganic Chemistry 2014; 19(3):375-388

      10.    Jia Y, Zhou J, Liu HM, Huang KX*. Effect of methionine sulfoxide reductase B1 (SelR) gene silencing on peroxynitrite-induced F-actin disruption in human lens epithelial cells. Biochemical and Biophysical Research Communications 2014; 443(3): 876-881

      11.    Liu HM*, Bian WX, Liu SX, Huang KX. Selenium protects bone marrow stromal cells against hydrogen peroxide-induced inhibition of osteoblastic differentiation by suppressing oxidative stress and ERK signaling pathway. Biological Trace Element Research 2012; 150(1-3): 441-450

      12.    Liu HM*, Zeng BM, Jia FL. Direct growth of tellurium nanorod arrays on Pt/FTO/glass through a surfactant-assisted chemical reduction. Nanotechnology 22 (2011) 305608 (10pp)

      13.    Liu HM*,Zhang CC, Huang KX.Lanthanum chloride suppresses oxysterol-induced ECV-304 cell apoptosis via inhibition of intracellular Ca2+ elevation, oxidative stress, ERK and NF-kappaB signal pathways. Journal of Biological Inorganic Chemistry 2011; 16(5): 671-681

      14.    Liu HM*, Lu Q, Huang KX. Selenium suppressed hydrogen peroxide-induced vascular smooth muscle cells calcification through inhibiting oxidative stress and ERK activation. Journal of Cellular Biochemistry 2010; 111(6): 1556-1564

      15.    Du SQ, Liu HM, Huang KX*. Influence of SelS gene silence on beta-Mercaptoethanol- mediated endoplasmic reticulum stress and cell apoptosis in HepG2 cells. Biochimica et Biophysica Acta-General Subjects 2010; 1800: 511-517

      16.    Liu HM, Wang TB, Huang KX*.Cholestane-3beta,5alpha,6beta-triol-induced reactive oxygen species production promotes mitochondrial dysfunction in isolated mice liver mitochondria. Chemico-Biological Interactions2009; 179(2-3): 81- 87

      17.    黄开勋*刘红梅,徐辉碧. 血管硒蛋白与动脉粥样硬化. 化学进展 2009; 21: 831-835

      18.    刘松秀,刘红梅*,黄开勋. 低温湿化学还原法制备Bi2Te3单晶纳米棒. 无机材料学报2008;23(2):305-308 

      19.    Liu HM*, Liu SX, Huang KX. Low-temperature chemical route to bismuth-doped tellurium single-crystalline nanorods. Materials Letters 2008;62:1983-1985 

      20.    Liu HM*, Yuan L, Xu SJ, Wang K. Endothelial cells and macrophages regulation of vascular smooth muscle cell calcification modulated by cholestane-3b, 5a, 6b-triol. Cell Biology International 2007; 31: 900-907

      21.    Liu HM, Cheng Y, Lu JF, Li RC, Wang K*. The mechanism of kinetic inhibition of Cu2+-induced oxidation of low density lipoprotein by lanthanide ions. Journal of Inorganic Biochemistry 2006; 100: 1280- 1289

      22.    Liu HM*, Zhang TL, Xu SJ, Wang K. Effect of La3+ on osteoblastic differentiation of rat bone marrow stromal cells. Chinese Science Bulletin2006; 51: 31-37

      23.    Liu HM, Yuan L, Xu SJ, Zhang TL*, Wang K. Cholestane-3b, 5a, 6b-triol inhibited osteoblastic differentiation and promoted apoptosis in bone marrow stromal cells. Journal of Cellular Biochemistry2005;96:198-208

      24.    Tang R, Liu HM, Wang TB, Huang KX*. Mechanism of selenium inhibition of cell apoptosis induced by oxysterols in rat vascular smooth muscle cells. Archives of Biochemistry and Biophysics 2005; 441:16-24

      25.    Liu HM, Yuan L, Xu SJ, Zhang TL*, Wang K.Cholestane-3b, 5a, 6b-triol promotes vascular smooth muscle cell calcification. Life Sciences 2004; 76: 533-543

      26.    Huang KX*, Liu HM, Chen ZX, Xu HB. Role of selenium in cytoprotection against cholesterol oxide-induced vascular damage in rats. Atherosclerosis 2002;162:137-144

获奖与荣誉

华中科技大学优秀教师班主任

华中科技大学青年教师教学竞赛二等奖

湖北省优秀学士学位论文指导教师

优秀党支部书记