报告题目：Stereocontrolled glycosidic bond formation: A challenge and an inspiration for organic chemists

报 告 人：David Crich（Wayne State University  教授）

报告时间：2016年6月6号下午3：00

报告地点：化学楼二楼一号会议室

报告人简介：Crich教授是世界糖化学乃至有机化学领域最顶尖的研究者之一，已在Nature Chem，JACS，Angew等国际高水平期刊发表论文370篇，其中包括60篇以上发表在JACS和Angew上，目前H因子为51。曾任法国天然产物化学研究所所长，获得过美国化学会及英国皇家化学会多项荣誉和奖励，目前是美国Wayne州立大学教授，Orgnic Lett 编委会成员。主要研究方向是自由基化学和糖化学。

Abstract: Just as chemistry is the all enabling science, carbohydrate chemistry enables glycoscience, and is in turn itself enabled by glycosidic bond forming reactions – known as glycosylation or glycosidation and one of organic chemistries biggest black boxes. The lecture will discuss work underway in the Crich laboratory conducted with the aim of demystifying the glycosylation reaction so as to provide a stronger basic for the rational development of improved glycosylation reactions. A particular focus of the lecture will be on the development of cation clock reactions for the determination of the molecularity of glycosylation reactions. Other reactions to be discussed include a variety of deamination reactions in the context of sialic acid chemistry.